The Isolation of Poliomyelitis Virus
نویسندگان
چکیده
This series of papers is concerned with the isolation of poliomyelitis virus in the human disease. In them the attempt has been made to compare the ease or difficulty with which the virus may be isolated from several different anatomical sites in man, during and after acquisition of the disease, or exposure to it. In papers I and II (1) virus tests on oropharyngeal swabs and washings are compared with tests on the feces. Paper III (2) is concerned with the duration of excretion of virus during the convalescent period. In number IV (3), tests for virus in the blood are reported. There have been a number of comparable studies carried out within the past 35 years; most of them have been published recently, and most of them deal with one particular aspect of the many complex problems involved. Some of these studies have been reported from this laboratory (4 to 7). In the present series, however, we have tried to relate several different aspects one with another; methods for the detection of the virus have been more delicate, the clinical material has been more extensive, and serial tests have been made on the same patients or group of patients in several instances. From the results certain new conclusions can be drawn with regard to the presence of poliomyelitis virus in different anatomical sites in man. We do not believe, however, that we are yet far enough along to attempt to interpret these findings from an epidemiological standpoint. We do believe on the other hand, that when certain obvious gaps in present knowledge are filled in by other studies, the epidemiological interpretation of the findings can go forward quite rapidly.
منابع مشابه
Poliomyelitis Viruses in Tissue Culture 5
Tissue culture inoculation has replaced the production of the experimental disease in the monkey as the method of choice for the direct isolation and antigenic identification of virus from materials obtained from poliomyelitis patients.""' 12,16,18 In addition, tissue-culture methods have now made practical serologic tests for antibody development in man after natural poliomyelitis infection' '...
متن کاملThe Virus Reference Laboratory (Report)
POLIOMYELITIS, ASEPTIC MENINGITIS AND ENCEPHALITIS, 1955, 1956 AND 1957. Paralytic Poliomyelitis. The laboratory diagnosis of poliomyelitis has been undertaken in the department since August, 1955. Our aim has been to receive specimens from all notified paralytic cases, and in practice, thanks to the co-operation of the physicians, we have received specimens from over (seems) 95 per cent. of th...
متن کاملIi. Poliomyelitic Virus in Urban Sewage
In two out of three large urban epidemics of poliomyelitis the virus of this disease has been detected in samples of sewage. From one of the sites it was found repeatedly. Both positive sites were located in the vicinity of isolation hospitals, and we believe that the findings indicate that this virus can be transported, for short distances at least, through the medium of flowing sewage.
متن کاملThe Isolation of Poliomyelitis Virus from Human Extra-neural Sources. Ii. Comparison of Virus Content of Blood, Oropharyngeal Washings, and Stools of Contacts.
متن کامل
The Isolation of Poliomyelitis Virus from Human Extra-neural Sources. I. Comparison of Virus Content of Pharyngeal Swabs, Oropharyngeal Washings, and Stools of Patients.
متن کامل
The Detection of Poliomyelitis Virus in so Called Abortive Types of the Disease
Experiments are reported which describe the isolation of poliomyelitis virus from the throats of two patients during an attack of so called abortive poliomyelitis (Wickman type), or what we have termed characteristic minor illnesses in association with poliomyelitis. This finding represents added evidence in favor of the belief, previously held by many observers, that certain types of minor ill...
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تاریخ انتشار 2013